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Affects of Osteoarthritis What Areas Does Osteoarthritis Affect? Osteoarthritis most often occurs in the hands (at the ends of the fingers and thumbs), spine (neck and lower back), knees, and hips. Source: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases. www.niams.nih.gov Lifestyle effects Financial effects difficulty participating in everyday personal and family joys and responsibilities. job limitations limitations on daily activities feelings of helplessness anxiety depression wages lost because of disability. the cost of treatment LifeART Collection Images Copyright © 1989-2001 by Lippincott Williams & Wilkins, Baltimore, MD Osteoarthritis