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Long-Term Side Effects of Stem Cell Transplant Bone damage; if damage is severe, the patient will need to have part of the bone and joint replaced. Cataracts (damage to the lens of the eye) Damage to the thyroid gland that causes problems with metabolism Side Effects of SCT Damage to the ovaries causing infertility and loss of menstrual periods Radiation damage to the lungs, causing shortness of breath Graft-versus-host disease