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Peripheral arterial disease (PAD) Carotid artery disease Coronary artery disease (CAD) Atherosclerosis This is when plaque builds up in the coronary arteries. These arteries supply oxygen-rich blood to your heart. When blood flow to your heart is reduced or blocked, it can lead to chest pain and heart attack. CAD also is called heart disease, and it's the leading cause of death in the United States. This happens when plaque builds up in the carotid arteries. These arteries supply oxygen-rich blood to your brain. When blood flow to your brain is reduced or blocked, it can lead to stroke. This occurs when plaque builds up in the major arteries that supply oxygen-rich blood to the legs, arms, and pelvis. When blood flow to these parts of your body is reduced or blocked, it can lead to numbness, pain, and sometimes dangerous infections. Source: National Heart Lung and Blood Institute, National Institutes of Health. nhlbi.nih.gov Atherosclerosis is a disease in which plaque builds up on the insides of your arteries. Arteries are blood vessels that carry oxygen-rich blood to your heart and other parts of your body. Affect of Atherosclerosis