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Soft, muffled speech Loss of facial expression Small or cramped handwriting Balance problems Parkinson disease Depression Slowness of movements Shuffling walk Stiffness Shaking (tremor) Parkinson disease is a progressive movement disorder. This means the symptoms will gradually worsen over time. In people with Parkinson disease a vital chemical in the brain, dopamine, slowly decreases. Dopamine makes smooth and coordinated muscle movement possible. A loss of dopamine leads to symptoms of Parkinson disease. What is Parkinson Disease?